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Sebagian besar situs menyediakan laman khusus yang memuat informasi tersebut. Temukan kebijakan privasi situs saat kamu mengunjungi5.2 Structural Birth Defects Valproate may cause fetal harm when administered to the Expecting girl. Pregnancy registry knowledge present that maternal valproate use may cause neural tube defects and other structural abnormalities (e.g., craniofacial defects, cardiovascular malformations, hypospadias, limb malformations). The speed of congenital malformations between infants born to mothers utilizing valproate is about 4 times bigger than the speed amongst babies born to epileptic moms employing other anti-seizure monotherapies.
There's no proof that divalproex is productive for extensive-expression use in mania (more time than three weeks). In the event your health care provider would love you to consider this drug for an extended stretch of time, they're going to Verify if you continue to need to have the drug frequently.
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The problem you’re endeavoring to address may well not get better. You may also experience much more Negative effects from this drug if you're taking it on and off.
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12.1 System of Motion Divalproex sodium dissociates for the valproate ion within the gastrointestinal tract. The mechanisms by which valproate exerts its therapeutic effects haven't been proven.
Because of divalproex sodium's toxicity, use in little ones more youthful than two a long time of age requires Excessive warning.
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Proof suggests that folic acid supplementation ahead of conception and during the first trimester of here pregnancy decreases the danger for congenital neural tube defects in the general inhabitants [see Use in Specific Populations (8.1)].
Table 4 lists treatment-emergent adverse reactions which had been noted by ≥ 5% of individuals within the large dose valproate group, and for which the incidence was increased than while in the lower dose group, within a controlled demo of Depakote monotherapy procedure of elaborate partial seizures.
Getting warfarin with divalproex sodium may well improve the levels of warfarin in your body. Your physician might monitor your INR more normally if you might want to acquire divalproex sodium together with warfarin.
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